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Posted Mon Aug 23 2010: from MedicalNewsToday:
PMO Compounds Show Promise Against Deadly Ebola, Marburg Viruses
US scientists have discovered two compounds from a family known as antisense phosphorodiamidate morpholino oligomers, or PMOs, can protect monkeys infected with Ebola and Marburg viruses from going on to develop lethal hemorrhagic fever, which has a 90 per cent fatality rate in humans; and they are now proceeding with clinical trials. The "proof of concept" study that led to these findings was a collaboration between the US Army Medical Research Institute of Infectious Diseases (USAMRIID) based at Fort Detrick, Maryland, and AVI BioPharma, a Washington-based biotechnology firm, and was published in the 22 August advanced online issue of Nature Medicine. There are currently no vaccines or effective treatments for the Ebola and Marburg filoviruses, which are commonly transmitted through blood and bodily fluids. However, infection can also occur via the aerosol route, which is why they are a cause of grave concern as potential weapons in biological warfare or terrorism.
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