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Posted Tue Apr 29 2008: from Uro Today:
Human Exposure to Endocrine Disrupters and Semen Quality
We propose that environmental factors, including exposure to endocrine disrupting chemicals, may be represented in this idiopathic category of diagnosis. Endocrine disrupters are proposed to modulate or dysregulate the endogenous endocrine system via competitive or non-competitive binding at steroid hormone receptors, changes to synthesis, metabolism or transport of hormones or by changes in gene expression. Significant laboratory evidence supports endocrine disruption as a mechanism of action for several types of chemicals including polychlorinated biphenyls (PCBs), bisphenol A (BPA), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), p,pí-DDE (p,p'-dichlorodiphenyl dichloroethylene)- the major breakdown product of DDT and mixtures such as pesticides. Though there is a relative paucity of population-based studies examining the effects of exposure to endocrine disrupters on human semen quality, it may be cautiously interpreted that endocrine disruption due to organochlorine exposures may be manifested as reduced sperm motility and morphology.
[Read more stories about: endocrine disruptor, PCBs, bisphenol A]

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