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Posted Fri Apr 3 2009: from Environmental Science and Technology:
In the mix: equine estrogens used in HRT
Equine estrogens, presumably derived from human hormone replacement therapy (HRT) medications, are pervasive in effluents from sewage treatment works (STW) in the U.K., according to a comprehensive study published in ES&T (DOI 10.1021/es803135q). The study demonstrates, both in vitro and in vivo, that these compounds can have substantial effects on the reproductive systems of fish. In most HRT regimens, women ingest estrogens derived from the urine of pregnant mares. The researchers routinely detected one of these equine estrogens, equilenin (Eqn), and a metabolite, 17β-dihydroequilenin (17β-Eqn), in STW discharge from multiple facilities, says lead author Charles Tyler of the University of Exeter (U.K.).
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